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  "slug": "biomed-research",
  "question": "What new biomedical research appeared this week?",
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  "as_of": "2026-06-11T00:00:11Z",
  "updated_at": "2026-06-11T00:00:11Z",
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  "answer": "This week, new biomedical research published on June 9, 2026, includes findings from the 2021 Global Burden of Disease Study on the burden of Chronic Kidney Disease in China from 1990-2021, appearing in medRxiv Epidemiology & Public Health. bioRxiv Cancer & Immunology Translation published research on the reconstruction of septin higher-order nano-size structures in ovarian cancer cells, uncovering susceptibility to the septin-targeting small molecule UR214-9. The same day, bioRxiv Protein Structure & Drug Discovery featured two studies: one on the discovery of ILT3 (LILRB4) small molecule inhibitors by affinity selection-mass spectrometry, revealing the druggability of a neuroimmune checkpoint in Alzheimer's Disease, and another on targeting the myeloid immune checkpoint ILT3 (LILRB4) with small molecules to reprogram suppressive tumor immunity. Additionally, on June 8, 2026, bioRxiv Cancer & Immunology Translation published research on how the loss of Arginase 2 promotes lung metastasis in immune-competent hosts via Nitric Oxide Synthase 2-Dependent Th17 Response. Synthesized from 344 manifests produced by 27 monitored biomedical research sources in the last 7 days, including bioRxiv, medRxiv, HHS.",
  "coverage": {
    "manifests_matched": 344,
    "manifests_cited": 5,
    "producing_sources": 27,
    "cohort_label": "biomedical research",
    "cohort_size": null,
    "window": "168h"
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  "manifests": [
    {
      "manifest_id": 1781046633866632561,
      "headline": "Burden of Chronic Kidney Disease in China, 1990-2021: Findings from the 2021 Global Burden of Disease Study",
      "summary": "",
      "source_name": "medrxiv-epidemiology-public-health",
      "source_display": "medRxiv Epidemiology & Public Health",
      "url": "https://medrxiv.org/content/10.64898/2026.06.06.26355056v1.full",
      "published": "2026-06-09",
      "claim_count": 11,
      "streams": [
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      "headline": "Reconstruction of septin higher-order nano-size structures in ovarian cancer cells uncover susceptibility to the septin-targeting small molecule UR214-9",
      "summary": "",
      "source_name": "biorxiv-cancer-immunology-translation",
      "source_display": "bioRxiv Cancer & Immunology Translation",
      "url": "https://biorxiv.org/content/10.64898/2026.06.09.731048v1.full",
      "published": "2026-06-09",
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      "headline": "Discovery of ILT3 (LILRB4) Small Molecule Inhibitors by Affinity Se-lection-Mass Spectrometry Reveals Druggability of a Neuroimmune Checkpoint in Alzheimers Disease",
      "summary": "",
      "source_name": "biorxiv-protein-structure-drug-discovery",
      "source_display": "bioRxiv Protein Structure & Drug Discovery",
      "url": "https://biorxiv.org/content/10.64898/2026.06.05.730337v1.full",
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      "headline": "Loss of Arginase 2 Promotes Lung Metastasis in immune-competent hosts via Nitric Oxide Synthase 2-Dependent Th17 Response",
      "summary": "",
      "source_name": "biorxiv-cancer-immunology-translation",
      "source_display": "bioRxiv Cancer & Immunology Translation",
      "url": "https://biorxiv.org/content/10.64898/2026.06.04.730112v1.full",
      "published": "2026-06-08",
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      "headline": "Targeting the Myeloid Immune Checkpoint ILT3 (LILRB4) with Small Molecules Enables Reprogramming of Suppressive Tumor Immunity",
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      "source_name": "biorxiv-protein-structure-drug-discovery",
      "source_display": "bioRxiv Protein Structure & Drug Discovery",
      "url": "https://biorxiv.org/content/10.64898/2026.06.05.730341v1.full",
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